In our research, HIF1α regulated its transcription and expression by directly binding to ZEB1, and knockdown of ZEB1 in HCC cells effectively inhibited CAF-induced EMT and metastasis, suggesting that ZEB1 was a downstream key factor of HIF1α in the adjustment of CAF-derived CCL5 induced EMT and metastasis in HCC cells. This evidence concerns the gene ZEB1 and hepatocellular carcinoma.