Antibodies targeting RBD, S proteins and NP of SARS-CoV-2, SARS-CoV-1 and human coronaviruses (229E, NL63, OC43, HKU1) were assessed for isotype/subclass (IgM, IgG, IgG1-4, IgA1-2) and binding with FcγR (FcγR2aH, FcγR2aR, FcγR2b, FcγR3aV, FcγR3aF) and C1q, totaling 315 features, in 14 COVID-19 and 5 non-COVID-19 respiratory samples and paired plasma. Here, CD40LG is linked to COVID-19.