TP53 and lung cancer: Conditioned medium from H1299L858R cells overexpressing GFP-p53 inhibited the migration of macrophages (Fig. 5A) and cancer cells, H1299L858R (Fig. 5B) and A549 cells (Fig. 5C), suggesting that p53-mediated secreted factors from lung cancer cells are involved in lung cancer progression by regulating cancer cells and the tumor-associated microenvironment.