The data indicated that THP-1 cells treated with conditioned medium from H1299L858R lung cancer cells with GFP-p53 overexpression decreased the levels of CD206 and IL6 but increased the level of IL10, suggesting that p53 in lung cancer cells can inhibit the polarization of M2 macrophages, which can promote cancer metastasis (Fig. 4A). This evidence concerns the gene TP53 and cancer.