In addition to the effect of p53 within cancer cells, when the TP53 was knocked out in mice with EGFRL858R-induced lung cancer, not only did the size of the tumor increase, but marked immune cell infiltration was also observed around cancer cells, indicating that p53, as a tumor suppressor, inhibited not only cancer cells directly but also M2-macrophage differentiation. The gene discussed is TP53; the disease is lung carcinoma.