TP53 and lung cancer: To study the role of p53 in sex-dependent lung cancer progression, TP53 was knocked out in mice with EGFRL858R-induced lung cancer and EGFRL858R x TP53+/− male and female mice to delineate the role of p53 in sex-dependent lung cancer development induced by doxycycline for 1.5 months (Fig. 2A and Supplementary Fig. 2).