Meanwhile, Cal/ICG@MPs significantly promoted DC maturation (Fig. 8g and Supplementary Fig. 45a) and tumor infiltration of CD8+ T cells (Fig. 8h and Supplementary Fig. 45b), activated CD8+CD69+ T (Fig. 8i and Supplementary Fig. 45c), CD8+IFN-γ+ T (Fig. 8j and Supplementary Fig. 45d) and CD8+ IL-2+ T cells (Fig. 8k and Supplementary Fig. 45e), while decreased the ratios of Tregs (Fig. 8l and Supplementary Fig. 45f) and PMN-MDSCs (Fig. 8m and Supplementary Fig. 45g) in the contralateral tumors upon 808 nm laser irradiation. The gene discussed is IFNG; the disease is neoplasm.