Correspondingly, the highest numbers and ratios of activated CD69+CD8+ T (Fig. 6c and Supplementary Figs. 31a, 32b), CD8+IFN-γ+ T (Fig. 6d and Supplementary Figs. 31a, 32c), and CD8+IL-2+ T cells (Fig. 6e and Supplementary Figs. 31a, 32d) were detected in tumor tissues of Cal/ICG@MPs with 808 nm laser irradiation-treated group compared with other groups, revealing that Cal/ICG@MPs efficiently activated antitumor immunity upon 808 nm laser irradiation. This evidence concerns the gene CD8A and neoplasm.