CD8A and neoplasm: As Cal/ICG@MPs-triggered PTT efficiently induces ICD and activates CD8+ T cells, and Cal/ICG@MPs regulate CAFs to recruit CD8+ T cells and decrease the antigen-mediated AICD of CD8+ T cells, the tumor immune microenvironment was then investigated in stroma-rich H22 tumor-bearing mice after intravenous injection of PBS, ICG, Cal/ICG, ICG@MPs, Cal@MPs, or Cal/ICG@MPs derived from H22 cells twice every 2 days, followed with or without 808 nm laser irradiation at tumor sites for 10 min (Fig. 6a).