In summary, the data in this study show that Cal/ICG@MPs efficiently target tumor tissues and regulate CAFs to reduce tumor ECM, leading to not only the enhanced tumor accumulation and penetration of ICG to enhance PTT-induced CD8+ T cell-mediated antitumor immunity, but also the enhanced tumor infiltration of CD8+ T cells and ameliorated CAF-induced antigen-mediated AICD of CD8+ T cells in response to PTT with the reshaped tumor immune-suppressive microenvironment. Here, CD8A is linked to neoplasm.