TGFB1 and neoplasm: In view of the enhanced tumor accumulation and penetration of ICG, and the improved tumor immune microenvironment, the antitumor activity of Cal/ICG@MPs against large tumors was determined in stroma-rich H22 tumor-bearing mice constructed by co-injection of TGF-β-activated skin fibroblasts and H22 cells upon 808 nm laser irradiation.