Meanwhile, the numbers and ratios of CD8+ T cells in tumor tissues of mice undergoing ICG@MPs-triggered PTT markedly decreased, while loading Cal significantly abrogated the decrease in the numbers and ratios of CD8+ T cells induced by ICG@MPs with 808 nm laser irradiation (Fig. 5j, k), further confirming that Cal/ICG@MPs-triggered CAF regulation efficiently ameliorates CAF-induced antigen-mediated AICD of CD8+ T cells in response to PTT. Here, CD8A is linked to neoplasm.