Importantly, Cal/ICG@MPs-caused CAF regulation significantly decreased CAF-induced AICD of these CD8+ T cells when CAFs processed and cross-presented tumor antigens derived from the Cal/ICG@MPs-triggered PTT-induced ICD of tumor cells, as evidenced by the decreased expression of MHC-I, PD-L2 and FasL in CAFs after treatment with Cal/ICG@MPs upon 808 nm laser irradiation and the correspondingly enhanced CD8+ T-cell proliferation and decreased CD8+ T-cell apoptosis. The gene discussed is PDCD1LG2; the disease is neoplasm.