Moreover, the expression of MHC-I (Fig. 5g), FasL (Fig. 5h), and PD-L2 (Fig. 5i) in CAFs was significantly reduced in stroma-rich H22 tumor-bearing mice after intravenous injection of Cal/ICG@MPs upon 808 nm laser irradiation compared with ICG@MPs with 808 nm laser irradiation-treated group. Here, PDCD1LG2 is linked to neoplasm.