Pathologic activation of GSK3β signaling leads to neurodegenerative/neuropsychiatric diseases (Busciglio et al., 1995; Takashima et al., 1996; Ferreira et al., 1997; Mao et al., 2009), but its involvement in oxidative stress-induced neurodevelopmental disorders and cognitive deficits is uncharacterized. This evidence concerns the gene GSK3B and Cognitive impairment.