The IK1 current decrease was linked to an increased risk for arrhythmia (59), and the differential regulation of Kir2.1 and Kir2.2 by PKC in the heart is a druggable target in conditions like Andersen’s syndrome, which is associated with impaired PIP2 regulation of Kir2.1. The gene discussed is KCNJ2; the disease is cardiac arrhythmia.