As overwhelming neutrophil and macrophage accumulation are critical to the development of periodontitis (57, 58) and our in vitro data showed SGK1 inhibition enhances production of MIP-2, we next examined whether SGK1 inhibition affects inflammatory cell infiltration by staining tissue sections with H&E (Fig. 6, C and D). The gene discussed is CXCL2; the disease is periodontitis.