The results showed that compared with the MI group, the protein and mRNA levels of p-p38MAPK in the myocardial tissue of the MI+SB203580 group were significantly decreased and the expression levels of autophagy markers Beclin-1 and LC3 were decreased, but the expression level of APOO showed no significant change (Fig. 7A-C). Here, APOO is linked to myocardial infarction.