IPO7 and pachyonychia congenita: Then immunohistochemical staining was used to detect the expression of IPO7 protein in the tumor tissue and paracancerous tissue of PC patients, and the representative images are shown in Fig. 1C. The statistical analysis showed that IPO7 expression was remarkably up-regulated in PC tissues compared with that in paracancerous tissues, and the difference was statistically significant (Fig. 1D).