GSDMD and COVID-19: Interestingly, roles for GSDMD downstream of caspases have been posited to mediate inflammatory pathology during SARS–CoV-2 infection (13), though clinical trials testing inhibitors of GSDMD in COVID-19 patients were not promising (8) and SARS–CoV-2 infection studies in GSDMD genetically deficient animal models have not yet been performed.