2018b; Wu et al. 2020). In our study, we detected these parameters related to cardiac function in MI/R mice and found similar changes in MI/R mice. However, after PA treatment, the abnormal LVER, LVFS and LVESD changes in MI/R mice were reversed. Moreover, previous studies have reported that high levels of cTnI, cTnT, CK-MB and LDH are detected in patients with acute myocardial infarction (Lim et al. 2019). In addition, increased expression of myocardial injury markers has been observed in I/R rats (Huang et al. 2020). This evidence concerns the gene TNNI3 and acute myocardial infarction.