Moreover, [11C]CFT also displays a high affinity for serotonin transporters (SERT) in addition to DAT in the midbrain and previous studies have shown that midbrain SERT distribution is significantly different between PD and MSA-P groups or between PD and PSP groups [34, 36], which may be another important factor suggesting the DAT-Net to pay attention to the tracer binding in midbrain for the differential diagnosis. The gene discussed is SLC6A4; the disease is Parkinson disease.