MSH2 and colorectal carcinoma: In contrast, while MSH2 is inactivated in only 10% to 20% of sporadic cases of CRC (28, –, 30), germ line mutations in MSH2 are one of the most common causes of Lynch syndrome, a hereditary cancer syndrome in which individuals are at increased risk of developing several cancers, including colorectal, endometrial, urinary tract, small bowel, ovarian, stomach, and biliary tract (31).