In contrast, while MSH2 is inactivated in only 10% to 20% of sporadic cases of CRC (28, –, 30), germ line mutations in MSH2 are one of the most common causes of Lynch syndrome, a hereditary cancer syndrome in which individuals are at increased risk of developing several cancers, including colorectal, endometrial, urinary tract, small bowel, ovarian, stomach, and biliary tract (31). Here, MSH2 is linked to Lynch syndrome.