HRH1 and neoplasm: Actually, our present study further examined the genotypes of rs901865 and rs346074 in five OSCC cell lines (SCC9, HSC-3, HSC-3M, SAS, and OECM1) and found that OECM1 cells carrying the rs901865 CT genotype and the rs346074 TT genotype expressed lower HRH1 protein levels compared to SAS, HSC-3, and HSC-3M cells carrying the CC genotype of both SNPs, suggesting that the T allele of rs901865 or rs346074 may produce a decrease in HRH1 levels in OSCC and subsequently cause smaller tumor sizes in OSCC patients carrying one minor allele of rs901865 or rs346074.