In addition, early primary prevention ICD implantation should be considered in patients with DCM and a confirmed LMNA, RBM20, PLN, and FLN mutation guided by risk factors (NSVT during ambulatory ECG monitoring, LVEF < 45% at first evaluation, male sex, and non-missense mutations (insertion, deletion, truncations, or mutations affecting splicing)) [43]. This evidence concerns the gene PLN and familial dilated cardiomyopathy.