Based on our previous conclusions that quercetin inhibited the expression of HIF-α; inhibiting HIF-α decreased the expression of lncRNA NEAT1 and inhibition of lncRNA NEAT1 also reduced the expression of HMGB1, we next aimed to explore whether quercetin inhibits the lncRNA NEAT1/HMGB1 pathway through HIF-1α and further relieves the injury and apoptosis of CI-AKI cells. Here, HMGB1 is linked to acute kidney injury.