In this sense, we here present original data regarding the impact of ΔNp73 in metastatic cell homing and growth in lungs in vivo and in blood and lymphatic vessels formation in colon cancer and identified its specific effectors implicated in these processes, BDNF and the putative EMAP‐II‐VEGFC‐VEGFR3 axis. Here, BDNF is linked to malignant colon neoplasm.