Individual AUC values for BDNF for discriminating premalignant individuals from controls were 96.9% (sensitivity 83.3% and specificity 100%), 87.5% (sensitivity 90% and specificity 65.0%) for CRC patients from controls, and 92% (sensitivity 68.4% and specificity 100%) for all patients from controls (Fig. 3B). The gene discussed is BDNF; the disease is colorectal carcinoma.