Among others, we found an important association between the overexpression of ∆Np73 and the VEGFC‐EMAP‐II‐VEGFR3 axis and the brain‐derived neurotrophic factor (BDNF) regulation of lymphangiogenesis, vasculogenesis and metastasis, and further demonstrated the usefulness of BDNF as a potential CRC biomarker able to discriminate between CRC and non‐CRC patients with high sensitivity and specificity. Here, BDNF is linked to colorectal carcinoma.