Despite the fact that these lymphomas originate from fundamentally different cells, with a B‐cell origin for cHL4 and a T‐cell origin for ALCL,5 both lymphomas have several features in common: both have lost expression of lineage‐specific surface markers and both have constitutively active NFKappaB, NOTCH1, AP1 and JAK‐STAT signalling.6, 7. The gene discussed is NFKB1; the disease is lymphoma.