One third of the frequent altered genes in this report were also observed in the French cohort 23, including TP53, MDM2, CDK4, MYC, and CDKN2A, among which CDK4, MDM2, and CDKN2A were the top three frequent GAs in this study, while the rest of frequent GAs, especially the amplification of MCL1, GNAS, and FGFR1 might be more frequent specifically in Chinese STS patients or specific histologic subtypes. The gene discussed is CDKN2A; the disease is telomere syndrome.