IgE, IL-4, and IL-9 concentrations did not affect the risk of complicated appendicitis in the crude (Table 3) or the adjusted analysis (Table 4): IgE aOR 0.53 (95% CI 0.329–1.181, p = 0.12), IL-4 aOR 1.08 (95% CI 0.59–1.99, p = 0.81), and IL-9 aOR 1.05 (95% CI 0.93–1.19, p = 0.46). Here, IGHE is linked to appendicitis.