The combination of ECC-BYF III and electroacupuncture was significantly superior to electroacupuncture in upregulating SIRT1, showing that it can upregulate SIRT1 and inhibit the acetylation of NF-κB. Combined with the results of inflammatory factors, the combination of ECC-BYF III and electroacupuncture can inhibit inflammation by regulating SIRT1/NF-κB signaling, thus playing an important role in the treatment of COPD. Here, NFKB1 is linked to chronic obstructive pulmonary disease.