Here, we use the theory of the TCM internal-external combined therapy theory as a guide, aimed to investigate the anti-inflammatory effect of ECC-BYF III, electroacupuncture (EA), and the combination of ECC-BYF III and EA in rats with COPD through the SIRT1/NF-κB signaling. This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.