On day 23, 2ME2 had significantly lowered Ang II-induced hypertension (Figure 2: A. systolic BP; 151 ± 1 vs. 141 ± 1 mmHg, B. diastolic BP; 107 ± 1 vs. 95 ± 1 mmHg, C. mean BP; 127 ± 1 vs. 117 ± 1 mmHg; p < 0.01). The gene discussed is AGT; the disease is hypertensive disorder.