AGT and hypertensive disorder: Notably, Ang II-induced hypertension was substantially blunted by 2ME2 treatment by day 15 and was maintained until day 17 (Figure 1: A. systolic BP; 159 ± 2 vs. 140 ± 2 mmHg, B. diastolic BP; 111 ± 1 vs. 94 ± 3 mmHg, and C. mean BP; 132 ± 1 vs. 114 ± 2; p < 0.001).