Although 2ME2 attenuated Ang II-induced hypertension, heart rate in 2ME2 treated group versus control consistently decreased from day 1 (375 ± 1 vs. 358 ± 1 BPM; p < 0.001) up to day 23 (370 ± 1 vs. 311 ± 1 BPM; p < 0.001) independent of Ang II infusion. Here, AGT is linked to hypertensive disorder.