TP53, as a tumor suppressor protein, can produce anti-inflammatory reactions in the lungs and has a potential therapeutic effect in pneumonia, whose dysfunction is associated with acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary hypertension, pneumonia and tuberculosis, and so on [75]. Here, TCHP is linked to pulmonary arterial hypertension.