TP53 and breast angiosarcoma: The results of network topology analysis showed that the 5 active compounds most connected to the key targets were quercetin, luteolin, beta-carotene, kaempferol, and naringenin, and the top 6 key targets of connectivity were prostaglandin G/H synthase 2 (PTGS2), caspase-3 (CASP3), RAC-alpha serine/threonine-protein kinase (AKT1), transcription factor AP-1 (JUN) [, cellular tumor antigen p53 (TP53), and vascular endothelial growth factor A (VEGFA), which indicated that the above compounds and targets were critical and had important implications in SLBZP for treating BA and AC.