Naringenin, having immunomodulatory, anticancer, antimutation, anti-inflammatory, antioxidant, antiproliferative, antiarthritis, and anticarcinogenic effects, can be used for treating osteoporosis, cancer, cardiovascular disease, and rheumatoid arthritis, which exhibits lipid-lowering and insulin-like properties, can inhibit allergen-induced airway inflammation and airway responsiveness, and inhibit NF-κB activity in a mouse model of asthma [64–66]. This evidence concerns the gene INS and rheumatoid arthritis.