IL-6 and IL-8 have been proven to play important roles in psoriasis, and both of them can initiate STAT3 and JNK MAPK pathway, thus involving in regulating cell inflammation and proliferation of keratinocytes (Mori et al., 2011; Chen et al., 2015; Fu et al., 2015). The gene discussed is MAPK8; the disease is psoriasis.