Upregulation of PLOD2 has been observed in several malignancies such as bladder cancer (Miyamoto et al., 2016), lung cancer (Kocher et al., 2021), gastric cancer (Song et al., 2021), head and neck squamous cell cancer (Xin et al., 2021), breast cancer (Gilkes et al., 2013), etc. Kiyozumi et al. showed that PLOD2 was significantly associated with peritoneal dissemination in gastric cancer (Kiyozumi et al., 2018). This evidence concerns the gene PLOD2 and lung cancer.