The immune-related pathways were highly enriched in LIHC by KEGG GSEA (NSE≥1.0, FDR<0.25), including Fc-gamma-r-mediated phagocytosis, primary immunodeficiency, TCR signaling pathway, antigen processing and presentation, JAK-STAT pathway, leukocyte transendothelial migration, chemokine signaling pathway and so on, which are shown in red (Figure 4A). This evidence concerns the gene SOAT1 and inborn error of immunity.