BCL2 and cancer: For example, knocking down proteins involved in MDR such as p-glycoprotein which act as efflux pumps and Bcl-2 (anti-apoptotic gene) which is responsible for developing cancer by preventing release of mitochondrial cytochrome c and regulates survival of cancer cells over apoptosis through the non-pump mechanism, could improve chemotherapeutic efficacy (Ma et al., 2013), (Ray, 2020).