PIEZO2 and Ataxia: Loss-of-function mutations in human PIEZO2 results in profoundly decreased proprioception leading to ataxia and dysmetria (Chesler et al., 2016), and gain-of-function mutations of PIEZO2 are directly linked to distal arthrogyposis type 5, Gordon syndrome, and Marden-Walker syndrome (Coste et al., 2013; McMillin et al., 2014).