For an instance, the frequently detected mutations in bladder cancers such as TERT, FGFR3, TP53, PIK3CA, and KRAS were significantly altered in urine cfDNAs showing cancer detection rate using these five gene panel with a AUC confidence interval of 0.94 (Ou et al., 2020). This evidence concerns the gene FGFR3 and urinary bladder carcinoma.