Huntington’s disease is a genetic neurodegenerative disease causedby a mutation in the huntingtin (HTT) gene, current research explores the use ofcyclodextrin nanoparticles (CDs) loaded with siRNA in order to downregulate themutated HTT gene.49 The modified CD-siRNA nanoparticles were synthesized following apreviously established protocol and then were characterized usingFourier-Transform infrared spectroscopy (FTIR), nuclear magnetic resonance(NMR), and high-resolution mass spectrometry (HRMS). Here, HTT is linked to neurodegenerative disease.