MMP2 and glioblastoma: As annexin A5 was shown to be overexpressed in human GBM cells (e.g., U-87 MG and U-118 MG), the expression of annexin A5 was silenced by shRNA, which showed a significant reduction in cell invasion capability, MMP-2 expression, temozolomide resistance, and Akt phosphorylation in annexin A5-shRNA-treated cells.