Monitoring the copy numbers of four tumour suppressors of 3p25 and 3p21 chromosomal loci—VHL, SETD2, PBRM1 and BAP1—we did not find a significant difference between the ccRCC tumorous and the normal adjacent kidney tissues indicating that the loss of the functions of these genes is frequently derived from other genetic alterations than deletion [7]. This evidence concerns the gene BAP1 and nonpapillary renal cell carcinoma.