We showed that by calculating the median transcription values of the four ccRCC tumour suppressors of 3p25 and 3p21 chromosomal loci—VHL, SETD2, PBRM1, and BAP1–, complemented that of the p14ARF, normal and ccRCC tissues can be distinguished. Here, SETD2 is linked to nonpapillary renal cell carcinoma.