VHL and nonpapillary renal cell carcinoma: The first identified oncogenic driver of ccRCC was the tumour suppressor von-Hippel-Lindau (VHL) gene [4], followed by the further revelation of SET domain containing 2, histone lysine methyltransferase (SETD2), BRCA1 associated protein 1 (BAP1) and polybromo 1 (PBRM1) among the others.