As a risk factor, Itgb2 had been shown to accelerate the development of myocardial infarction, atherothrombotic cerebral infarction (Lehmkuhl et al., 1996; May et al., 2002; Yamaguchi et al., 2006), and diabetic nephropathy (Geng et al., 2019) through the cell adhesion molecule pathway. The gene discussed is ITGB2; the disease is diabetic kidney disease.