Current studies demonstrated that Aβ and NFTs could promote the activation of the NLRP3 inflammasome pathway in microglia, and NLRP3 deficiency attenuated neuroinflammation and Aβ accumulation in the AD mice model (Yin et al., 2017; Ising et al., 2019). This evidence concerns the gene NLRP3 and Alzheimer disease.