Taken together, the above results indicated that c-Myc inhibitors (10,058-F4 and 10,074-G5) had a moderate synergistic effect with dFdC in Panc-1 and Mia-Paca cells, suggesting that c-Myc inhibitors could enhance the inhibitory effect of dFdC in pancreatic cancer cells, thereby increasing the dFdC sensitivity. The gene discussed is MYC; the disease is familial pancreatic carcinoma.