Purinergic signalling, mediated by ATP and its breakdown products, is crucial in maintaining this astrocytic cell-to-cell communication (Franke et al., 2012) and increasing evidence have drawn considerable attention to an important role of astrocytic purinergic receptors (PRs) in epilepsy and MS from the initial stages of diseases (Narcisse et al., 2005; Dona et al., 2009; Franke and Illes, 2014; Rassendren and Audinat, 2016; Amadio et al., 2017; Brambilla, 2019; Domercq and Matute, 2019; Illes, 2020; Nikolic et al., 2020; Sidoryk-Wegrzynowicz and Struzynska, 2021). Here, P2RX7 is linked to epilepsy.