Several studies emphasized naringenin inhibits NF-κB and MAPK activation in different cell types such as adipocytes, hepatocytes, cancer cells, and macrophages to exert anti-inflammatory and antioxidant effects on acute and chronic inflammation including colitis, arthritis, gastric cancer, and obesity (Zeng et al., 2018). This evidence concerns the gene NFKB1 and arthritic joint disease.