NFKB1 and obesity due to melanocortin 4 receptor deficiency: Several studies emphasized naringenin inhibits NF-κB and MAPK activation in different cell types such as adipocytes, hepatocytes, cancer cells, and macrophages to exert anti-inflammatory and antioxidant effects on acute and chronic inflammation including colitis, arthritis, gastric cancer, and obesity (Zeng et al., 2018).