This study confirmed that the molecular mechanisms of Chinese classical music in the treatment of hypertension and inhibition of myocardial remodeling all come from the downregulation of β1/cAMP/PKA and α1/PLC/PKC signaling pathway, and does not affect the bronchial β2/PI3K/Akt signaling pathway. The gene discussed is HSPG2; the disease is Hypertension.