TNF and metabolic dysfunction-associated steatotic liver disease: In this study we found that after the treatment with TGQZD, the CGI-58 levels increased significantly, while NLRP3 inflammasome protein, IL-1β, and TNF-α levels decreased significantly, which also suggested that TGQZD exerted certain protective effects on NAFLD-induced rats through the regulation of CGI-58 and NLRP3 inflammasome (Figure 9).