Increased Lp-PLA2 levels has been observed in vascular endothelial dysfunction, atherosclerotic plaque inflammation, and necrotic core formation in plaques, which has led to regard Lp-PLA2 as a predictive marker for atherosclerosis-related CV diseases (CVD) and a promising therapeutic target (Huang et al., 2020). This evidence concerns the gene PLA2G7 and atherosclerosis.