The remaining tag-SNP, rs78178583, is an intronic A-to-C substitution located within the promoter flanking region of the gene (ENSR00000934514), and therefore it is plausible that it could be tagging genetic variability modulating cPLA2 expression, which could in turn affect the risk of CKD, since cPLA2 expression has been related to renal damage both in humans and animal models (Montford et al., 2016). The gene discussed is PLA2G4A; the disease is chronic kidney disease.