In this sense, it has been demonstrated that L. donovani induces the expansion of hematopoietic stem cells (HSCs) and differentiation of GMP (granulocyte-monocyte progenitors) cells into Ly6Chi (an inflammatory monocytes) with a more permissive profile to infection, characterized by the expression of regulatory markers such as Sca1, Galactin-3, MHC-II and IL-10 (22). The gene discussed is IL10; the disease is infection.