In addition to restoring the function of both CD4+ T and CD8+ T lymphocytes and decreasing parasite numbers, blocking the PD1/PDL1 pathway with anti-PDL1 antibodies reverses inhibition of caused by L. donovani, a mechanism used by the parasite to subvert the host’s autophagic machinery to encourage survival and induce the establishment of infection (73). Here, CD274 is linked to infection.