In the absence of any tolerability issues, the recommended Phase 2 dose (RP2D) for a small molecule PD-L1 agent is likely the dose that achieves a reliable immune response/pharmacodynamics (assessed by monitoring T cells or other immune cells in the tumor microenvironment) and hints of clinical efficacy or exposure that shows anti-tumor efficacy in preclinical models. Here, CD274 is linked to neoplasm.