Using MC38-CEA colon and 4T1 triple-negative breast murine carcinoma models, the combined application of Entinostat (HDACi), N-803 (IL-15 superagonist) and cancer vaccine was found to promote an anticancer effect by facilitating the infiltration of activated CD8+T cells and activating T cell responses to various tumor-associated antigens in the tumor microenvironment (127). The gene discussed is IL15; the disease is neoplasm.