A previous study reported that suppressing HDAC6 can decrease the expression level of LAG-3, TIM-3 and PD-1, relieve the suppressive function of Treg cells and upregulate TIL cytolytic function in melanoma patients, potentially indicating that HDAC6 is involved in the regulatory pathways of LAG-3 and TIM-3. The gene discussed is HAVCR2; the disease is melanoma.