CD274 and non-small cell lung carcinoma: In cisplatin-resistant non-small cell lung cancer cells, a decreased constitutive photomorphogenesis protein 1 (COP1) level caused the increased accumulation of c-Jun, which suppressed HDAC3 expression and facilitated acetylation of the PD-L1 promoter at the H3 site, thereby upregulating the expression of PD-L1.