IL1R1 and pulmonary arterial hypertension: (28), using Caspase1/11-/- mice, Il1r-/- mice, and melatonin-treated mice, revealed that MLT reduces hypoxia-induced pulmonary vascular endothelial leakage in the pulmonary arterial hypertension (PAH) model, related to the effects of inflammasome-associated endothelial permeability.