The results also revealed that the expression of miR-30d-5p could significantly inhibit the expression of Beclin-1 and Atg5- by targeting the 3′UTR levels of Beclin-1 and Atg5- and inhibit the ischemia-induced polarization of microglia to M1 (Jiang et al., 2018). Here, BECN1 is linked to ischemia.