CHRNB4 and Alzheimer disease: Similarly, SDK1, ANK1, and CHRNB4, which are targeted by cg04680535, cg05066959, and cg17179314, respectively, also have either a certain gene expression level regulated by a specific methylation status (De Jager et al., 2014; Kanno et al., 2014; Yan et al., 2019) or an epigenomic change during AD pathogenesis (Li et al., 2010; De Jager et al., 2014).