In a murine model of PD induced by 1-methyl-4-phenyl-4-propionoxypiperidine (MPTP), ginger extract was shown to protect neurons against apoptosis, increase dopamine levels in the globus pallidus and striatum, and reduce TNF-α, NO, and ROS levels, resulting in this way in improved PD symptoms of motor coordination disorder and bradykinesia [101]. The gene discussed is TNF; the disease is Parkinson disease.