MAPT and Alzheimer disease: Immunoregulation can then be added to TEMT’s other two identified mechanisms of action in the AD brain: (1) disaggregation of Aβ and tau aggregates/oligomers (Arendash et al., 2010; Dragicevic et al., 2011), and (2) mitochondrial (energy) enhancement (Dragicevic et al., 2011; Arendash et al., 2019).