In Alzheimer’s disease there is not only a higher prevalence in women than men (Plassman et al., 2007; Carter et al., 2012), but it is also associated with a higher tau cerebrospinal fluid level, cortical tau load, and degree of neurodegeneration in females (Filon et al., 2016; Hohman et al., 2018). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.