We have also observed that the degenerative changes were accompanied by inflammation, as shown by increased Iba-1 expression in the gray and white matter in homozygous P301L mice (Figure 3), confirming previous reports in different mouse tauopathy mouse models (Allen et al., 2002; Higuchi et al., 2002; Lin et al., 2005; Yoshiyama et al., 2007; Rudzinski et al., 2008). Here, AIF1 is linked to tauopathy.