MAPT and tauopathy: Related studies in animal models of tauopathy have shown the deposition of phosphorylated tau and neurofibrillary tangles in the SC in several different strains (Ishihara et al., 1999; Spittaels et al., 1999; Duff et al., 2000; Probst et al., 2000; Götz et al., 2001; Allen et al., 2002; Higuchi et al., 2002; Lin et al., 2003, 2005; Zehr et al., 2004; Yoshiyama et al., 2007).