MAPT and Alzheimer disease: This group includes progressive supranuclear palsy, corticobasal degeneration, and a number of sporadic and familial frontotemporal dementias and Alzheimer’s disease, that ketamine acts on postsynaptic neurons where beta-amyloid is also deposited into extracellular plaques in addition to tau (Grundke-Iqbal et al., 1986).