More recently, the AMPK/Nrf2 signaling pathway is the focus of research and petatewalide B, i.e., a bakkenolide-type sesquiterpine, alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway in the human-derived neuroblastoma cell line SH-SY5Y (52). Here, NFE2L2 is linked to neuroblastoma.